Antibody na-anọpụ iche

Onyonyo egosipụtara na-egbochi mmadụ ịnọpụ iche

Nkọwa dị mkpirikpi:

SARS-CoV-2 bụ nje RNA gbachiri ekpuchi na otu.stranded, bụ nke beta.cov genera na ezinụlọ coronaviridae.1ts genome RNA na-edekọ protein na-abụghị nke na-emepụta ihe na ọtụtụ protein nhazi, gụnyere spike (s), envelopu (E), akpụkpọ ahụ (M) na nucleocapsid (N) protein.

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Nkọwa ngwaahịa

Mkpado ngwaahịa

pathogenesis:

Protein S bụ maka njikọ nje na ịbanye n'ime sel ndị ọbịa, nke mejupụtara subunits abụọ na-arụ ọrụ, s1 na s2 na ngalaba nnabata nnabata (RBD) dị n'ime mpaghara s1. RBD nke protein SARS-CoV-2 S na-emekọrịta ihe. ya na angiotensin na-atụgharị enzyme 2 (Ace2), na-ebute mgbanwe mgbanwe na mpaghara s2 nke na-arụpụta.

na ngwakọta nje na ịbanye n'ime cell ezubere iche.Proteases nzuzo mmadụ, dị ka TMPRss2 na furin, na-abanye n'ime mkpụrụ ndụ viral.

Proteases ndị a na-akwalite ntinye nje n'ime sel ndị ọbịa site na proteolysis nke ma protein s1, s2 na Ace2.

eji eme ihe:

Emebere ihe mgbochi SARS-CoV-2 Neutralizing Antibody Rapid Test Kit maka nchọpụta in vitro qualitative nke SARS-CoV-2 na-ewepụ ọgwụ mgbochi ọrịa n'omume ọbara mmadụ.Mgbochi mgbochi SARS-CoV-2 bụ ihe dị mkpa maka inyocha ịdị irè nke ọgwụ mgbochi SARS-CoV-2.The reagent bụ maka neutralizing antibody nchọpụta na samples si n'otu n'otu mgbe ịgba ọgwụ mgbochi ọrịa ma ọ bụ gbakere na coV1D.19.Ngwa ahụ ga-enyekwara aka na nyocha nke coV1D.19 ugbu a banyere mgbasa nke sero, nyocha nke mgbochi anụ ụlọ, ogologo oge nke mgbochi nchebe, ịdị irè nke ndị na-achọ ọgwụ mgbochi dị iche iche yana nyocha ọrịa na anụmanụ.

ọnọdụ nchekwa na nkwado:

Reagents niile dị njikere iji dị ka ewepụtara ya.Ngwa reagent anaghị emepe emepe kwụsiri ike na 4"c 30"c maka ọnwa 24 n'otu oge.Ekwesịrị iji 1t mee ihe n'ime awa 1 ozugbo emeghere obere akpa ahụ.Ejila ngwa ngwa ifriizi ma ọ bụ kpughee ngwa ahụ n'elu 37"c n'oge nchekwa.

Nkọwapụta:

1 ule / igbe;5 ule / igbe;25 ule / igbe;50 ule / igbe.

Usoro nnwale:

Emepela obere akpa ahụ ruo mgbe ị dị njikere ịme ule, yana a na-atụ aro ka iji ule single.use n'okpuru iru mmiri dị ala (RHs70%) n'ime awa 1.

1.Kwe ka ihe niile kit na ihe nlere nweta iru okpomọkụ n'ime ụlọ n'etiti 18"c～26"c tupu nnwale.2.Wepụ kaadị ule ahụ na obere akpa foil ma tinye n'elu ala akọrọ dị ọcha.

3.1 Chọpụta kaadị ule maka ụdịdị ọ bụla.

4.Use dropper iji nyefee otu dobe (1) nke serum, plasma ma ọ bụ ọbara dum (40uL) n'ime ihe nlele nke ọma na kaadị ule, na-esote otu dobe ihe nchekwa.

5.malite ngụ oge wee gụọ nsonaazụ na nkeji iri na ise.

Nkọwapụta nsonaazụ ule:

1nsụgharị ule dị ka eserese agba na-esote (Dịka N'okpuru).

1.1f agba ike dị ala karịa G4, na-egosi ịta nke neutralizing mgbochi karịrị 200 PRNT50 2.1f agba ike dị n'etiti G4 na G6, na-egosi ịta nke neutralizing antibody bụ gburugburu 100 PRNT50 3.1f agba ike dị nso G7. , na-egosi itinye uche bụ nke neutralizing mgbochi bụ 50 PRNT50

4.Nchọpụta njedebe bụ 50 PRNT50

5.f ike agba dị ike karịa G7, gosi nsonaazụ na-adịghị mma.

Nke gara aga: Nleba anya nrịbama nkwojiaka dijitalụ akpaaka

Osote: Broshuọ-PocRoc®SARS-CoV-2 Antigen Rapid Test K0429